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A rare disease calls for a special mouse model

For the rarest of rare genetic conditions, a one-of-a-kind mouse could light a path to new treatments.

Drug normalizes learning in Down syndrome mice

DAPT, a drug that reduces β amyloid levels in the brains of Alzheimer's disease patients, ameliorates cognitive defects in the Ts65Dn Down syndrome mouse model.

Down syndrome is caused partly by gene under-expression, not just over-expression

Conventional thinking has been that Down syndrome phenotypes are caused by over-expression of trisomy chr 21 genes. However, gene under-expression is also partly to blame.

Genetic Linkage between Down syndrome and reduced cancer incidence revealed